Clinical and diagnostic evaluation of the effectiveness of treatment of optic neuropathy in patients with edematous endocrine ophthalmopathy

The aim: to conduct a clinical and diagnostic evaluation of the effectiveness of the administration of a complex of drugs in the region of hemolymphocirculation in optical neuropathy in patients with edematous form of endocrine ophthalmopathy.Materials and methods. The results of diagnosis and treatment of 31 patients (61 eyes) with optical neuropathy on the background of edematous exophthalmos in endocrine ophthalmopathy were analyzed. To identify hidden forms of optical neuropathy, such studies were prescribed as computer microperimetry on a confocal infrared ophthalmoscope, a complex of electroretinographic studies: registration of maximum ERG, oscillatory potentials. Latent forms of optical neuropathy were detected in 22 cases. In 9 cases, there were obvious forms of optical neuropathy. All patients underwent a 10-day course of intensive complex treatment, consisting of injections into the region of hemolymphocirculation (projection of the pterygoid fossa) No. 6–8 (No. 3–4 on each side) with an interval of 24 hours of a drug mixture, the formulation of which included Lidocaine 20 mg, Dexazone 4 mg, Hemase 3000 UNITS, Dalargin 1 mg.Results. In all patients, there was a pronounced positive dynamics in the form of a significant (from 0.6 to 1.0) increase in visual acuity, a decrease in exophthalmos from (2.0 to 3.0 mm), an increase in color and contrast sensitivity.Conclusions. Due to the violation of venous and lymphatic outflow due to thickening of extraocular muscles and retrobulbar fiber, injections into the hemolymphocirculation region (projection of the pterygoid fossa) of drugs with a wide range of decongestant and metabolic effects are justified, effective and safe

Comprehensive Treatment of Noninfectious Uveitis Accompanied by Macular Edema with the Use of Autologous Platelet-Rich Plasma

Background. A common cause of visual impairment in patients with non-infectious uveitis is macular edema, developing in 38–84 % of cases. Plasma enriched with platelets is widely used in various branches of medicine, the effectiveness of its use in the treatment of non-infectious uveitis, accompanied by macular edema, has not been sufficiently investigated. Aim: To evaluate the effectiveness of autologous platelet-rich plasma in the complex treatment of non-infectious uveitis accompanied by macular edema.Material and methods. The study was conducted on the basis of the academician S.N. Fyodorov Eye Microsurgery Federal State Institution in the period from 2016 to 2018, which included 123 people (176 eyes) from 18 to 50 years with non-infectious uveitis, accompanied by macular edema: 46 men, 77 women. Patients were divided into 2 groups. The main group consisted of patients receiving autologous platelet-rich plasma and anti-inflammatory treatment; the comparison group consisted of patients receiving anti-inflammatory treatment. The results of visual acuity, intraocular pressure, biomicroophthalmoscopy, optical coherence tomography of the macular zone, microperimetry, ultrasound examination on the side of the affected eye were evaluated. Statistical processing of the data was carried out in the program Statistica 10.Results. Maintenance of autologous platelet-rich plasma contributes to a statistically significant improvement in visual acuity on the 10th day of treatment by 64.2 %, a decrease in the thickness of the retina in fovea by 36.3 % and an increase in retinal photosensitivity by 34.6 % compared to the group of patients receiving only anti-inflammatory treatment. Conclusions. The use of autologous platelet-rich plasma in the complex treatment of non-infectious uveitis allows to accelerate the natural mechanisms of tissue regeneration, contributing to the reduction of macular edema, and improve visual performance

Data mining via ILP: The application of progol to a

As far as this author is aware, this is the first paper to describe the application of Progol to enantioseparations. A scheme is proposed for data mining a relational database of published enantioseparations using Progol. The application of the scheme is described and a preliminary assessment of the usefulness of the resulting generalisations is made using their accuracy, size, ease of interpretation and chemical justification

Combined Technique and Its Clinical and Pathogenetic Evaluation in Treatment of Central Serous Chorioretinopathy Using Subthreshold Microimpulse Laser Irradiation with a Wavelength of 577 nm in Combination with Injections of Platelet Autoplasma

Background. Lack of a holistic understanding of the etiology and pathogenesis of central serous chorioretinopathy (CSH), which determines the conduct of pathogenetic therapy, as well as the lack of effectiveness of treatment methods aimed at developing new pathology methods.Aims. To conduct a comparative therapeutic potential of a combination of subthreshold micropulse laser irradiation (SMILV) with a course of injection of autologous plasma enriched with platelets (TP) in CSH. To evaluate the effectiveness of SMILV with a wavelength of 577 nm with wing-injection injections of TP compared with SMIV monotherapy in the treatment of CSH. Consider issues of modern treatment of CSH, as well as determine the levels of cytokines in the tear fluid of patients with CSH before and after SMILV and SMILV + TP treatment.Methods and methods. The study was conducted on 60 patients (60 eyes) with CSH. Patients were divided into 2 groups: in the comparison group, patients received treatment only SMILV wavelength 577 nm, and in the experimental group – SMILV followed by the introduction of TP. TP was prescribed after 72 hours, 3 injections in the region of the pterygomaxillary fossa on the side of damage to the eyes, with an interval between injections of 72 hours.SMILV was performed on a Supra 577 nm laser machine (Quantel Medical, France) over the entire area of macular edema. Conclusion. Comparative analysis of clinical and functional results of treatment of central serous chorioretinopathy SMILV with a wavelength of 577 nm and a combination of SMILV with injections of autologous plasma enriched with platelets and the outcome of the disease revealed a greater effectiveness of combining SMILV with a course of injections of autologous plasma enriched with platelets

Managing Congestion in Vehicular Networks Using Tabu Search

© 2018, Springer Nature Switzerland AG. In this era of communication, exponentially growing networks bring a lot of challenges to address for smoother network functionalities. Among them is efficiency in handling packet traffic to avoid and control congestion. A particular case is applicable to Vehicular Ad-hoc Networks, which are known with unbalanced resource utilisation, communication overheads, high transmission delay and least transmission capacity. This paper aims to minimise the delay and jitter for enhancing the Quality of Service (QoS) in Vehicular Adhoc Networks (VANET) using tabu search algorithm with multi-channel allocation capability. We proposed a scheme that prioritises each message considering the basis of message type or its substances, such as crisis, reference point, and administration oriented etc., and uses tabu search for scheduling the transmission of queued messages in order to enhance the efficiency, security, and durability of VANET. A comprehensive simulation is conducted to validate the proposed scheme and to evaluate the performances in comparison with other state-of-the-art approaches

Persistence length of a polyelectrolyte in salty water: a Monte-Carlo study

We address the long standing problem of the dependence of the electrostatic persistence length $l_e$ of a flexible polyelectrolyte (PE) on the screening length $r_s$ of the solution within the linear Debye-Huckel theory. The standard Odijk, Skolnick and Fixman (OSF) theory suggests $l_e \propto r_s^2$, while some variational theories and computer simulations suggest $l_e \propto r_s$. In this paper, we use Monte-Carlo simulations to study the conformation of a simple polyelectrolyte. Using four times longer PEs than in previous simulations and refined methods for the treatment of the simulation data, we show that the results are consistent with the OSF dependence $l_e \propto r_s^2$. The linear charge density of the PE which enters in the coefficient of this dependence is properly renormalized to take into account local fluctuations.Comment: 7 pages, 6 figures. Various corrections in text and reference